Human interstitial retinoid-binding protein
نویسندگان
چکیده
منابع مشابه
Interphotoreceptor Retinoid Binding Protein; Myths and Mysteries
Although it is the major soluble protein component of the extracellular matrix bathing the photoreceptors, little is known about the structure and function of interphotoreceptor retinoid-binding protein (IRBP). The critical anatomic compartment it occupies cannot be overemphasized as through the involution of the optic vesicle, the retinal pigmented epithelium (RPE) comes in contact with the ne...
متن کاملIdentification, retinoid binding, and x-ray analysis of a human retinol-binding protein.
Two cellular retinol-binding proteins (CRBP I and II) with distinct tissue distributions and retinoid-binding properties have been recognized thus far in mammals. Here, we report the identification of a human retinol-binding protein resembling type I (55.6% identity) and type II (49.6% identity) CRBPs, but with a unique H residue in the retinoid-binding site and a distinctively different tissue...
متن کاملRetinoid-binding proteins: mediators of retinoid action.
Active vitamin A metabolites, known as retinoids, are essential for multiple physiological processes, ranging from vision to embryonic development. These small hydrophobic compounds associate in vivo with soluble proteins that are present in a variety of cells and in particular extracellular compartments, and which bind different types of retinoids with high selectivity and affinity. Traditiona...
متن کاملNormal cone function requires the interphotoreceptor retinoid binding protein.
11-cis-retinal is the light-sensitive component in rod and cone photoreceptors, and its isomerization to all-trans retinal in the presence of light initiates the visual response. For photoreceptors to function normally, all-trans retinal must be converted back into 11-cis-retinal through a series of enzymatic steps known as the visual cycle. The interphotoreceptor retinoid-binding protein (IRBP...
متن کاملInterphotoreceptor retinoid-binding protein promotes rhodopsin regeneration in toad photoreceptors.
Interphotoreceptor retinoid-binding protein (IRBP) has been hypothesized to function as an intercellular shuttle in the vertebrate eye, serving to transport retinoids between the retinal pigment epithelium (RPE) and photoreceptors in the process by which visual pigment is regenerated after photolysis. This hypothesis was tested in preparations utilizing the toad (Bufo marinus) eye and purified,...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1989
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)83169-6